Our biology team offers care and support of established cell lines to enable radiobiology assays.

We provide expansion, banking, and development of murine and human cell lines to suit your project requirements. We can also support your engineered cell lines.

01

Cell line supply & authentication

We source new cell lines from reputable suppliers like ATCC, and we authenticate them upon arrival. Our existing cell banks are authentic and mycoplasma-free, so rest easy knowing your study is primed for success.

02

Expansion, banking, and storage of desired cell lines

We are continuously expanding our in-house cell line database, offering a wide range of disease models and optimized lead times. Our cell banks can be expanded to enable project specific needs, such as radiobiology studies.

03

Cell line authentication

Our cell banks are authentic and mycoplasma-free, so rest easy knowing your study is primed for success.

04

In vitro Assays

Our experienced staff run a wide range of in vitro assays to answer your radiobiological questions.

In vitro Assays

RPT Labworks’ staff are experienced conducting in vitro assays with radiopharmaceuticals to test their function / efficacy, assess toxicity, and understand their impact on biological / biochemical processes.  

Functional/Efficacy Testing

RPT saturation and pharmacological property assays
Equilibrium binding affinity (Kd)
IC50
Binding Affinity (Ki)
Maximum binding capacity (Bmax)
Lipohilicity (Log P/Log D)
RPT cellular efficacy testing:
Efflux
Uptake and internalization
Subcellular fractionation
Metabolite analysis

Toxicity Assessments

Proliferation and viability testing
Clonogenic assay
Cytotoxicity assessments
Protease activity
Lactate dehydrogenase
Annexin V apoptosis assays
Dose response relationship assays
EC50

Biological and Biochemical Processes

In vitro cell phenotype and protein expression
Flow Cytometry
Protein and cell secretion analysis
Western blot
ELISA/EIA

Additional in vitro resources

External beam radiation (x-ray)

High-throughput assays to get your data to you as quickly and as accurately as possible.

We also facilitate relevant biological assays, including phenotypic changes to cells, and deeper biological studies, such as co-culture and migration assays, to gain a greater understanding of the radiobiological effects of your RPT of interest on multiple cell types.

DNA-DSB detection and more